DMP1 Protein Inhibits Angiogenesis, Could Lead to New Treatments Against Cancer and Other Diseases

This discovery also has taken to the registry of a patent by the three protagonists of the investigation: Doctor to Akeila Bellahcène, associated of at heart national greater investigation for the scientific research (NFSR) that is working with the project, Sophie Pirotte, a TELEVIE investigator (NFSR), and to professor Vincent Castronovo, the Laboratory' director of s. The Dr. Bellahcène been has interested in proteins of the brothers in several years. They are a glycoprotein family open pies initially for its paper in the formation of bones and teeth. Now it has been during for fifteen years that one that the laboratory of Liege was the first one to demonstrate that two of these proteins, sialoprotein of the bone (BSP) and osteopontin (OPN), is produced by the cancerous cells and plays probably a role in the progression of these cancers, remarkably with its implication in the formation of metastasis of the bone. These original observations, confirmed by other international equipment, abrieron the way for the numerous projects studying the role played by these two proteins in cancer. Upon until recently time, DMP1, known coverall for his paper in the mineralization of the teeth, it had not attracted the attention in terms of paper in the development and the progression of the cancer. But doctor Akeila Bellahcène' the majority of the recent investigation of s demonstrates that DMP1 also merits same the special attention. Indeed the results published in the demonstration of the blood of the newspaper that DMP1 is able to block angiogenesis. The angiogenesis is vital yet for the development of tumors beyond some cubical millimeters, as well as for the formation of metastasis. The work demonstrates that DMP1 prevents the endothelial cells (the cells what forms the new blood vessels on the course of the angiogenesis) to respond to VEGF, a molecular signal sent by the cancerous cells to activate the formation of new blood vessels of the feeder. The presence of DMP1 for the diverse stages that take to the formation of new capillaries: the endothelial cells are put in a reclinación of the nonproliferativo state. " In a model in alive of the angiogenesis related to the development of the tumor, we have demonstrated that to the tumors of the cancerous cells in those who overexpressed beforehand DMP1 had a growth reduced combined with vascularisation very modest in comparison with the tumors of the control, " it needs doctor Bellahcène. " The cover of these results indicates that DMP1 could represent a new molecule whose therapeutic implications on the other hand would go beyond their use in pathology of the cancer, " of the anti-angiogenesis; it indicates professor Vincent Castronovo, that directs the research laboratory of the metastasis in the ULg' s GIGA-ResearchUnit. " Indeed the processes of the angiogenesis induced by VEGF also take part in a significant way in the development and the progression of other pathologies such as reumatoide arthritis, psoriasis and retinopathy." diabetic